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Article

STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3 beta.

Diabetes - 1 May 2008

Moh Akira, Zhang Wenjun, Yu Sidney, Wang Jun, Xu Xuming, Li Jiliang, Fu Xin-Yuan

Abstract excerpt

OBJECTIVE: Glucose homeostasis is achieved by triggering regulation of glycogen synthesis genes in response to insulin when mammals feed, but the underlying molecular mechanism remains largely unknown. The aim of our study was to examine the role of the signal transducers and activators of transcription 3 (STAT3) in insulin signaling. RESEARCH DESIGN AND METHODS: We generated a strain of mice carrying a targeted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18268048
DOI: 10.2337/db06-1582

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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