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Article

Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.

The Journal of biological chemistry - 13 Aug 2004

Shi Hang, Tzameli Iphigenia, Bjørbaek Christian, Flier Jeffrey S

Abstract excerpt

Many proinflammatory cytokines and hormones have been demonstrated to be involved in insulin resistance. However, the molecular mechanisms whereby these cytokines and hormones inhibit insulin signaling are not completely understood. We observed that several cytokines and hormones that induce insulin resistance also stimulate SOCS3 expression in 3T3-L1 adipocytes and that SOCS3 mRNA is increased in adipose tissue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15181014
DOI: 10.1074/jbc.M403886200

Genes

SOCS3
IRS1
IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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