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Article

Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell

19 Dec 2013

Abstract excerpt

Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that miR-184 is silenced in the pancreatic islets of insulin-resistant mouse models and type 2 diabetic human subjects. Reduction of miR-184 promotes the expression of its target...

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PMID: 24361012
DOI: 10.1016/j.cmet.2013.11.015

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