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Article

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2015

Priyadarshini Medha, Villa Stephanie R, Fuller Miles, Wicksteed Barton, Mackay Charles R, Alquier Thierry, Poitout Vincent, Mancebo Helena, Mirmira Raghavendra G, Gilchrist Annette, Layden Brian T

Abstract excerpt

G protein-coupled receptors have been well described to contribute to the regulation of glucose-stimulated insulin secretion (GSIS). The short-chain fatty acid-sensing G protein-coupled receptor, free fatty acid receptor 2 (FFAR2), is expressed in pancreatic β-cells, and in rodents, its expression is altered during insulin resistance. Thus, we explored the role of FFAR2 in regulating GSIS. First, assessing the...

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Share to Acetates
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Clamp Technique

Share to Glucose Tolerance Test

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Insulin Secretion

Share to Receptors, Cell Surface

Share to Receptors, G-Protein-Coupled

Source

Open in PubMed Open full text

Identifiers

PMID: 26075576
DOI: 10.1210/me.2015-1007
PMCID: PMC4484778

Genes

FFAR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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