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Article

Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines

1 Mar 2005

Abstract excerpt

OBJECTIVE: Suppressor of cytokine signaling (SOCS) proteins negatively regulate signal transduction of several cytokines. Since cytokines participate in the pancreatic islet damage in type 1 diabetes, the aim of our study was to investigate the expression of SOCS-1, -2 and -3 in isolated human islets, in basal conditions and after exposure, in vitro, to a combination of interferon (IFN)-gamma, interleukin...

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Share to Chemokine receptors and signaling
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PMID: 15757867
DOI: 10.1530/eje.1.01856

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