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Article

Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.

The Journal of biological chemistry - 13 Aug 2004

Li Li, Grønning Line M, Anderson Per O, Li Suling, Edvardsen Klaus, Johnston Jim, Kioussis Dimitris, Shepherd Peter R, Wang Ping

Abstract excerpt

The suppressors of cytokine signaling (SOCS) family is thought to act largely as a negative regulator of signaling by cytokines and some growth factors. Surprisingly, the SOCS-6 transgenics had no significant defects in the cytokine signaling and hematopoietic system but displayed significant improvements in glucose metabolism. Insulin stimulation of Akt/protein kinase B was also potentiated. Biochemical analysis...

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Identifiers

PMID: 15123678
DOI: 10.1074/jbc.M312672200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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