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Article

Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.

Journal of thrombosis and haemostasis : JTH - 1 Sept 2012

Unsworth A J, Finney B A, Navarro-Nunez L, Severin S, Watson S P, Pears C J

Abstract excerpt

BACKGROUND: In comparison to the classical isoforms of protein kinase C (PKC), the novel isoforms are thought to play minor or inhibitory roles in the regulation of platelet activation and thrombosis. OBJECTIVES: To measure the levels of PKCθ and PKCε and to investigate the phenotype of mice deficient in both novel PKC isoforms. METHODS: Tail bleeding and platelet activation assays were monitored in mice and...

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Identifiers

PMID: 22812584
DOI: 10.1111/j.1538-7836.2012.04857.x
PMCID: PMC3532618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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