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Article

Essential role of class II PI3K-C2α in platelet membrane morphology.

Blood - 27 Aug 2015

Valet Colin, Chicanne Gaëtan, Severac Childerick, Chaussade Claire, Whitehead Maria A, Cabou Cendrine, Gratacap Marie-Pierre, Gaits-Iacovoni Frederique, Vanhaesebroeck Bart, Payrastre Bernard, Severin Sonia

Abstract excerpt

The physiologic roles of the class II phosphoinositide 3-kinases (PI3Ks) and their contributions to phosphatidylinositol 3-monophosphate (PI3P) and PI(3,4)P2 production remain elusive. Here we report that mice heterozygous for a constitutively kinase-dead PI3K-C2α display aberrant platelet morphology with an elevated number of barbell-shaped proplatelets, a recently discovered intermediate stage in the final...

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Source

Identifiers

PMID: 26109204
DOI: 10.1182/blood-2015-03-636670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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