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Article

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.

Nature medicine - 1 Sept 2004

Crittenden Jill R, Bergmeier Wolfgang, Zhang Yanyu, Piffath Crystal L, Liang Yuqiong, Wagner Denisa D, Housman David E, Graybiel Ann M

Abstract excerpt

Signaling through the second messengers calcium and diacylglycerol (DAG) is a critical element in many biological systems. Integration of calcium and DAG signals has been suggested to occur primarily through protein kinase C family members, which bind both calcium and DAG. However, an alternative pathway may involve members of the CalDAG-GEF/RasGRP protein family, which have structural features (calcium-binding...

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Source

Identifiers

PMID: 15334074
DOI: 10.1038/nm1098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.PMID 15334074Read ↗

Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis.Semantic proximity Read ↗

CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.Semantic proximity Read ↗

ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formation.Semantic proximity Read ↗

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding.Semantic proximity Read ↗

PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo.Semantic proximity Read ↗

Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2.Semantic proximity Read ↗

Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including HumanSemantic proximity Read ↗

Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis.Semantic proximity Read ↗

Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunctionSemantic proximity Read ↗

Reciprocal Signaling by Integrin and Nonintegrin Receptors during Collagen Activation of PlateletsSemantic proximity Read ↗

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.Semantic proximity Read ↗

Marked bleeding diathesis in patients with platelet dysfunction due to a novel mutation in RASGRP2, encoding CalDAG-GEFI (p.Gly305Asp).Semantic proximity Read ↗

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