Article
Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2.
Journal of thrombosis and haemostasis : JTH - 1 Jun 2010
Elvers M, Pozgaj R, Pleines I, May F, Kuijpers M J E, Heemskerk J M W, Yu P, Nieswandt B
Abstract excerpt
BACKGROUND: Agonist-induced platelet activation involves different signaling pathways leading to the activation of phospholipase C (PLC) beta or PLCgamma2. Activated PLC produces inositol 1,4,5-trisphosphate and diacylglycerol, which trigger Ca(2+) mobilization and the activation of protein kinase C, respectively. PLCbeta is activated downstream of Gq-coupled receptors for soluble agonists with only short...
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