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Article

PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2016

Münzer Patrick, Walker-Allgaier Britta, Geue Sascha, Geuss Eva, Hron Gregor, Rath Dominik, Eißler Daniela, Winter Stefan, Schaeffeler Elke, Meinert Monika, Schaller Martin, Greinacher Andreas, Schwab Matthias, Geisler Tobias, Kleinschnitz Christoph, Lang Florian, Gawaz Meinrad, Borst Oliver

Abstract excerpt

OBJECTIVE: Activation of platelets by subendothelial collagen results in an increase of cytosolic Ca(2+) concentration ([Ca(2+)]i) and is followed by platelet activation and thrombus formation that may lead to vascular occlusion. The present study determined the role of phosphoinositide-dependent protein kinase 1 (PDK1) in collagen-dependent platelet Ca(2+) signaling and ischemic stroke in vivo. APPROACH AND...

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Share to Platelet Activation
Share to 3-Phosphoinositide-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infarction, Middle Cerebral Artery

Share to Inositol 1,4,5-Trisphosphate

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Source

Identifiers

PMID: 27339458
DOI: 10.1161/ATVBAHA.115.307105

Genes

PDK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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PDK1 Determines Collagen-Dependent Platelet Ca2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo.PMID 27339458Read ↗

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