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Article

Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo.

Blood - 11 Mar 2010

Martin Valérie, Guillermet-Guibert Julie, Chicanne Gaétan, Cabou Cendrine, Jandrot-Perrus Martine, Plantavid Monique, Vanhaesebroeck Bart, Payrastre Bernard, Gratacap Marie-Pierre

Abstract excerpt

During platelet activation, phosphoinositide 3-kinases (PI3Ks) produce lipid second messengers participating in the regulation of functional responses. Here, we generated a megakaryocyte-restricted p110beta null mouse model and demonstrated a critical role of PI3Kbeta in platelet activation via a...

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PMID: 20065293
DOI: 10.1182/blood-2009-04-217224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20065293-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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