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Article

A118G Mu Opioid Receptor polymorphism increases inhibitory effects on CaV2.2 channels.

Neuroscience letters - 15 Aug 2012

Lopez Soto Eduardo J, Raingo Jesica

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the human OPRM1 gene result in common variants of Mu Opioid Receptors (hMORs). The A118G SNP occurs at high frequency in certain human populations and produces an aminoacidic substitution: N40D (hMOR-N to hMOR-D) at protein level. N40D is reported to alter pain thresholds and morphine efficacy. hMORs inhibit Ca(V)2.2 channels (N-type currents) at presynaptic nociceptor...

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Share to Analgesics, Opioid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 22796651
DOI: 10.1016/j.neulet.2012.06.074

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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