Article
The μ-opioid receptor gene polymorphism 118A>G weakens the pharmacological action of buprenorphine.
International journal of clinical pharmacology and therapeutics - 1 Nov 2020
Imai Hiromitsu, Morita Misaki, Morita Hajime, Ohyama Tetsuji, Tanaka Shimako, Uchida Shinya, Namiki Noriyuki, Uemura Naoto, Ohashi Kyoichi
Abstract excerpt
AIMS: Opioids are commonly used analgesics for moderate to severe pain, but levels of drug effect vary among individuals. As for the mechanisms underlying these individual differences, there have been reports suggesting effects of polymorphisms in the gene encoding μ-opioid receptor (OPRM1). However, whether these polymorphisms affect the actions of μ-opioid receptor partial agonists has yet to be determined....
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