Article
µ-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for pain.
Pharmacogenomics - 1 Nov 2013
Walter Carmen, Doehring Alexandra, Oertel Bruno G, Lötsch Jörn
Abstract excerpt
The human µ-opioid receptor variant 118 A>G (rs1799971) has become one of the most analyzed genetic variants in the pain field. At the molecular level, the variant reduces opioid receptor signaling efficiency and expression, the latter probably via a genetic-epigenetic interaction. In experimental settings, the variant was reproducibly associated with decreased effects of exogenous opioids. However, this...
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