Functional differences in the mu opioid receptor SNP 118A>G are dependent on receptor splice-variant and agonist-specific recruitment of β-arrestin.

doi:10.1111/cts.13888

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Article

Functional differences in the mu opioid receptor SNP 118A>G are dependent on receptor splice-variant and agonist-specific recruitment of β-arrestin.

Clinical and translational science - 1 Aug 2024

Patrick Casey, Ettah Utibeabasi, Nguyen Vu, Hart Caitlin, Atchley Evan, Mallela Krishna, Scheinman Robert I, Monte Andrew A

Abstract excerpt

The OPRM1 gene codes for the mu opioid receptor (MOR) and polymorphisms are associated with complex patient clinical responses. The most studied single nucleotide polymorphism (SNP) in OPRM1 is adenine (A) substituted by guanine (G) at position 118 (118A>G, rs1799971) leading to a substitution of asparagine (Asn) for aspartic acid (Asp) at position 40 in the N terminus of the resulting protein. To date, no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39118392
DOI: 10.1111/cts.13888
PMCID: PMC11310404

Genes

OPRM1

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