Article
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 1998
Bond C, LaForge K S, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong J A, Leal S M, Tischfield J A, Kreek M J, Yu L
Abstract excerpt
Opioid drugs play important roles in the clinical management of pain, as well as in the development and treatment of drug abuse. The mu opioid receptor is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. By sequencing DNA from 113...
Topics
- Base Sequence
- DNA Primers
- Genotype
- Heroin Dependence
- Humans
- Mutagenesis, Site-Directed
- Polymorphism, Genetic
- Receptors, Opioid, mu
- beta-Endorphin