Article

Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

2018-05-23

Abstract excerpt

<h4>Background</h4> The OPRM1 A118G gene variant (N40D) encoding the µ-opioid receptor (MOR) has been associated with dependence on opiates and other abused drugs but its mechanism is unknown. With opioid abuse-related deaths rising at unprecedented rates, understanding these mechanisms may provide a path to therapy. <h4>Methods</h4> Seven human induced pluripotent stem (iPS) cell lines from homozygous N40D subj...

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Literature Corpus work: 511a55b9-0555-5366-af8e-f5b5bad64d17
DOI: 10.1101/328898

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