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Article

The OPRM1 A118G Polymorphism Revisited: Recent Developments and Implications for Personalized Treatment.

Current pain and headache reports - 28 Apr 2026

Daybell Isaac, Wie Christopher, Johnson Brooks, Covington Stephen, Freeman John, Pew Scott, Maloney Jillian

Abstract excerpt

PURPOSE OF REVIEW: The OPRM1 A118G polymorphism, a single nucleotide variation in the mu-opioid receptor (MOR) gene, has been investigated for its role in opioid efficacy, addiction vulnerability, opioid-related adverse effects, and patient behavior. This review synthesizes recent findings, with a focus on clinical implications for patients with this polymorphism. RECENT FINDINGS: Recent research into the OPRM1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42047908
DOI: 10.1007/s11916-026-01485-5

Genes

OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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