Article
A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain.
The Journal of biological chemistry - 6 Mar 2009
Oertel Bruno Georg, Kettner Mattias, Scholich Klaus, Renné Christoph, Roskam Bianca, Geisslinger Gerd, Schmidt Peter Harald, Lötsch Jörn
Abstract excerpt
The single nucleotide polymorphism 118A>G of the human micro-opioid receptor gene OPRM1, which leads to an exchange of the amino acid asparagine (N) to aspartic acid (D) at position 40 of the extracellular receptor region, alters the in vivo effects of opioids to different degrees in pain-processing brain regions. The most pronounced N40D effects were found in brain regions involved in the sensory processing of...
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