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Article

Global Levels of H3K27me3 Track with Differentiation in Vivo and Are Deregulated by MYC in Prostate Cancer

18 Jun 2012

Abstract excerpt

Cancer cells and stem cells share a number of biological characteristics including abundant amounts of decondensed chromatin. However, the molecular correlates and the factors involved in altering chromatin structure in cancer cells are not well known. Here, we report that less differentiated stem-like cells in the basal compartment of human and mouse prostate contain lower levels of the polycomb heterochromatin...

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Share to Epigenetics and DNA Methylation
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PMID: 22713676
DOI: 10.1016/j.ajpath.2012.04.021

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