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Article

MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity

17 Jul 2020

Abstract excerpt

Localized prostate cancer develops very slowly in most men, with the androgen receptor (AR) and MYC transcription factors amongst the most well-characterized drivers of prostate tumorigenesis. Canonically, MYC up-regulation in luminal prostate cancer cells functions to oppose the terminally differentiating effects of AR. However, the effects of MYC up-regulation are pleiotropic and inconsistent with a poorly...

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PMID: 32681068
DOI: 10.1038/s41388-020-01389-7

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