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Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression

12 Apr 2017

Abstract excerpt

BACKGROUND: H3K27me3 histone marks shape the inhibition of gene transcription. In prostate cancer, the deregulation of H3K27me3 marks might play a role in prostate tumor progression. METHODS: We investigated genome-wide H3K27me3 histone methylation profile using chromatin immunoprecipitation (ChIP) and 2X400K promoter microarrays to identify differentially-enriched regions in biopsy samples from prostate cancer...

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Share to Epigenetics and DNA Methylation
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PMID: 28403887
DOI: 10.1186/s12885-017-3256-y

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