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Article

The polycomb group protein EZH2 is involved in progression of prostate cancer.

Nature - 10 Oct 2002

Varambally Sooryanarayana, Dhanasekaran Saravana M, Zhou Ming, Barrette Terrence R, Kumar-Sinha Chandan, Sanda Martin G, Ghosh Debashis, Pienta Kenneth J, Sewalt Richard G A B, Otte Arie P, Rubin Mark A, Chinnaiyan Arul M

Abstract excerpt

Prostate cancer is a leading cause of cancer-related death in males and is second only to lung cancer. Although effective surgical and radiation treatments exist for clinically localized prostate cancer, metastatic prostate cancer remains essentially incurable. Here we show, through gene expressi...

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Share to Gene Silencing
Share to Genes, Tumor Suppressor
Share to Polycomb Repressive Complex 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Predictive Value of Tests

Share to Prostatic Neoplasms

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Share to RNA, Small Interfering

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12374981
DOI: 10.1038/nature01075

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SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12374981-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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The polycomb group protein EZH2 is involved in progression of prostate cancer.PMID 12374981Read ↗

Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines.Semantic proximity Read ↗

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancerSemantic proximity Read ↗

The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late‐stage prostate cancerSemantic proximity Read ↗

A Polycomb Repression Signature in Metastatic Prostate Cancer Predicts Cancer OutcomeSemantic proximity Read ↗

Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies.Semantic proximity Read ↗

Mutations and deletions of PRC2 in prostate cancer.Semantic proximity Read ↗

Essential Role for Activation of the Polycomb Group (PcG) Protein Chromatin Silencing Pathway in Metastatic Prostate CancerSemantic proximity Read ↗

Polycomb-mediated silencing in neuroendocrine prostate cancerSemantic proximity Read ↗

Polycomb Group Protein Enhancer of Zeste 2 Is an Oncogene That Promotes the Neoplastic Transformation of a Benign Prostatic Epithelial Cell LineSemantic proximity Read ↗

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cellsSemantic proximity Read ↗

Androgens Suppress EZH2 Expression Via Retinoblastoma (RB) and p130-Dependent Pathways: A Potential Mechanism of Androgen-Refractory Progression of Prostate CancerSemantic proximity Read ↗

EZH2-associated tumor malignancy: A prominent target for cancer treatment.Semantic proximity Read ↗

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