Article

MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity

2019-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Localized prostate cancer develops very slowly in most men, with the androgen receptor (AR) and MYC transcription factors amongst the most well-characterized drivers of prostate tumorigenesis. Canonically, MYC up-regulation in luminal prostate cancer cells functions to oppose the terminally differentiating effects of AR. However, the effects of MYC up-regulation are pleiotropic and inconsistent...

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Literature Corpus work: ae9fbd6a-c199-5a5c-99c6-636a309b8fd0
DOI: 10.1101/848952

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