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Article

A Polycomb Repression Signature in Metastatic Prostate Cancer Predicts Cancer Outcome

15 Nov 2007

Abstract excerpt

The Polycomb Group (PcG) protein EZH2 is a critical component of a multiprotein complex that methylates Lys(27) of histone 3 (H3K27), which consequently leads to the repression of target gene expression. We have previously reported that EZH2 is overexpressed in metastatic prostate cancer and is a marker of aggressive diseases in clinically localized solid tumors. However, the global set of genes directly...

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PMID: 18006806
DOI: 10.1158/0008-5472.can-07-2498

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