Article
Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA.
Genome research - 1 Jun 2012
Statham Aaron L, Robinson Mark D, Song Jenny Z, Coolen Marcel W, Stirzaker Clare, Clark Susan J
Abstract excerpt
The complex relationship between DNA methylation, chromatin modification, and underlying DNA sequence is often difficult to unravel with existing technologies. Here, we describe a novel technique based on high-throughput sequencing of bisulfite-treated chromatin immunoprecipitated DNA (BisChIP-seq), which can directly interrogate genetic and epigenetic processes that occur in normal and diseased cells. Unlike...
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