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Article

Deficient histone acetylation and excessive deacetylase activity as epigenomic marks of prostate cancer cells

14 Oct 2009

Abstract excerpt

Aberrant epigenomic alterations include incorrect histone modifications involving altered expression of chromatin-modifying proteins. They contribute to gene silencing and carcinogenesis. The nature of the epigenomic alterations occurring with prostate cancer remains to be fully identified. The acetylation status of histone H3 in human prostate cancer cells was assessed with multiple acetylation sites at...

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PMID: 19885564
DOI: 10.3892/ijo_00000459

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