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Article

Genome rearrangements caused by depletion of essential DNA replication proteins in Saccharomyces cerevisiae.

Genetics - 1 Sept 2012

Cheng Edith, Vaisica Jessica A, Ou Jiongwen, Baryshnikova Anastasia, Lu Yong, Roth Frederick P, Brown Grant W

Abstract excerpt

Genetic screens of the collection of ~4500 deletion mutants in Saccharomyces cerevisiae have identified the cohort of nonessential genes that promote maintenance of genome integrity. Here we probe the role of essential genes needed for genome stability. To this end, we screened 217 tetracycline-regulated promoter alleles of essential genes and identified 47 genes whose depletion results in spontaneous DNA damage....

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Identifiers

PMID: 22673806
DOI: 10.1534/genetics.112.141051
PMCID: PMC3430531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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