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Article

Interstitial telomeric sequences promote gross chromosomal rearrangement via multiple mechanisms.

Proceedings of the National Academy of Sciences of the United States of America - 3 Dec 2024

Rosas Bringas Fernando R, Yin Ziqing, Yao Yue, Boudeman Jonathan, Ollivaud Sandra, Chang Michael

Abstract excerpt

Telomeric DNA sequences are difficult to replicate. Replication forks frequently pause or stall at telomeres, which can lead to telomere truncation and dysfunction. In addition to being at chromosome ends, telomere repeats are also present at internal locations within chromosomes, known as interstitial telomeric sequences (ITSs). These sequences are unstable and prone to triggering gross chromosomal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39602274
DOI: 10.1073/pnas.2407314121
PMCID: PMC11626172

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