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Article

A genome-wide screen for essential yeast genes that affect telomere length maintenance.

Nucleic acids research - 1 Jul 2009

Ungar Lior, Yosef Nir, Sela Yael, Sharan Roded, Ruppin Eytan, Kupiec Martin

Abstract excerpt

Telomeres are structures composed of repetitive DNA and proteins that protect the chromosomal ends in eukaryotic cells from fusion or degradation, thus contributing to genomic stability. Although telomere length varies between species, in all organisms studied telomere length appears to be controlled by a dynamic equilibrium between elongating mechanisms (mainly addition of repeats by the enzyme telomerase) and...

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Identifiers

PMID: 19386622
DOI: 10.1093/nar/gkp259
PMCID: PMC2709559

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