Article
Genes required for ionizing radiation resistance in yeast.
Nature genetics - 1 Dec 2001
Bennett C B, Lewis L K, Karthikeyan G, Lobachev K S, Jin Y H, Sterling J F, Snipe J R, Resnick M A
Abstract excerpt
The ability of Saccharomyces cerevisiae to tolerate ionizing radiation damage requires many DNA-repair and checkpoint genes, most having human orthologs. A genome-wide screen of diploid mutants homozygous with respect to deletions of 3,670 nonessential genes revealed 107 new loci that influence gamma-ray sensitivity. Many affect replication, recombination and checkpoint functions. Nearly 90% were sensitive to...
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