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Article

Frequent mutation of the p53 gene in human esophageal cancer.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990

Hollstein M C, Metcalf R A, Welsh J A, Montesano R, Harris C C

Abstract excerpt

Sequence alterations in the p53 gene have been detected in human tumors of the brain, breast, lung, and colon, and it has been proposed that p53 mutations spanning a major portion of the coding region inactivate the tumor suppressor function of this gene. To our knowledge, neither transforming mu...

Topics

Base Sequence
Cell Line
Codon
DNA, Neoplasm
Esophageal Neoplasms
Exons
Humans
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Polymerase Chain Reaction
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 2263646
DOI: 10.1073/pnas.87.24.9958
PMCID: PMC55293

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2263646-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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