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Article

Frequent mutation of the p53 gene in human esophageal cancer.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990

Hollstein M C, Metcalf R A, Welsh J A, Montesano R, Harris C C

Abstract excerpt

Sequence alterations in the p53 gene have been detected in human tumors of the brain, breast, lung, and colon, and it has been proposed that p53 mutations spanning a major portion of the coding region inactivate the tumor suppressor function of this gene. To our knowledge, neither transforming mutations in oncogenes nor mutations in tumor suppressor genes have been reported in human esophageal tumors. We examined...

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Identifiers

PMID: 2263646
DOI: 10.1073/pnas.87.24.9958
PMCID: PMC55293

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