Article
Prognostic significance of the p53 mutation in esophageal cancer.
Japanese journal of clinical oncology - 1 Oct 1996
Uchino S, Saito T, Inomata M, Osawa N, Chikuba K, Etoh K, Kobayashi M
Abstract excerpt
In the esophagus, alterations in the p53 tumor suppressor gene are associated with the development of preinvasive neoplastic lesions to invasive carcinoma. The role of p53 gene mutation in the progression of esophageal cancer still remains unclear. In this study, 82 DNA samples extracted from formalin-fixed, paraffin-embedded esophageal cancer tissues were analyzed for p53 mutation by polymerase chain...
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