Article
Clinical implications of p53 tumor suppressor gene mutation and protein expression in esophageal adenocarcinomas: results of a ten-year prospective study.
The Journal of thoracic and cardiovascular surgery - 1 May 2003
Casson Alan G, Evans Susan C, Gillis Amy, Porter Geoffrey A, Veugelers Paul, Darnton S Jane, Guernsey Duane L, Hainaut Pierre
Abstract excerpt
OBJECTIVE: This study was undertaken to characterize the spectrum of p53 alterations (mutations and protein expression) in surgically resected esophageal adenocarcinomas, and to correlate molecular alterations with clinicopathologic findings and outcome. METHODS: Between 1991 and 2001, 91 consecutive patients with esophageal adenocarcinomas underwent subtotal esophagectomy. No patient received induction therapy....
Topics
- Adenocarcinoma
- Esophageal Neoplasms
- Esophagectomy
- Female
- Genes, p53
- Hospital Mortality
- Humans
- Lymphatic Metastasis
- Male
- Multivariate Analysis
- Mutation
- Neoplasm Staging
- Prospective Studies