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Article

p53 mutations in esophageal tumors from high-incidence areas of China.

International journal of cancer - 29 May 1995

Liang Y Y, Estève A, Martel-Planche G, Takahashi S, Lu S H, Montesano R, Hollstein M

Abstract excerpt

Carcinomas of the upper digestive tract (squamous-cell carcinoma of the esophagus, adenocarcinoma of the cardia) from 24 patients residing in Linxian (China) and near-by high-incidence areas were analyzed for mutations in exons 5-8 of the p53 tumor-suppressor gene. Mutations were identified by polymerase chain reaction amplification and direct sequencing in 50% of the specimens. Eleven tumors harbored a single...

Topics

Adenocarcinoma
Adult
Aged
Carcinoma, Squamous Cell
Cardia
China
Esophageal Neoplasms
Female
Genes, p53
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Sequence Analysis, DNA

Stomach Neoplasms

Source

Identifiers

PMID: 7768632
DOI: 10.1002/ijc.2910610505

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7768632-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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