Article
p53 gene mutations in Barrett's epithelium and esophageal cancer.
Cancer research - 15 Aug 1991
Casson A G, Mukhopadhyay T, Cleary K R, Ro J Y, Levin B, Roth J A
Abstract excerpt
Genomic DNA was extracted from archival pathology specimens comprising 10 squamous and 14 adenocarcinomas, including 7 with Barrett's epithelium adjacent to tumor, and corresponding normal esophagus from the resection margin. The polymerase chain reaction was used to amplify selected exons of p53 which were analyzed for mutations using single-strand conformation polymorphism analysis. Mutations were localized to...
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