p53 gene mutations in esophageal squamous cell carcinoma and their relevance to etiology and pathogenesis: results in Japan and comparisons with other countries.

Abstract excerpt

Esophageal squamous cell carcinoma is a form of cancer that has varying incidence rates among different countries, distinct geographic areas and different ethnic groups. According to previous reports, p53 gene mutations have been identified in 20-80% of these tumors, and these mutations have occurred at an early stage. These findings suggest that such mutations play an important role in esophageal carcinogenesis,...

Topics

• Base Sequence
• Carcinoma, Squamous Cell
• Esophageal Neoplasms
• Genes, p53
• Humans
• Japan
• Molecular Sequence Data
• Mutation
• Polymerase Chain Reaction
• Prevalence