TP53 gene mutations and p53 protein immunoreactivity in malignant and premalignant Barrett's esophagus.

doi:10.1016/0016-5085(94)90225-9

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Article

TP53 gene mutations and p53 protein immunoreactivity in malignant and premalignant Barrett's esophagus.

Gastroenterology - 1 Oct 1994

Hamelin R, Fléjou J F, Muzeau F, Potet F, Laurent-Puig P, Fékété F, Thomas G

Abstract excerpt

BACKGROUND/AIMS: Limited data are available regarding TP53 gene alterations in Barrett's esophagus. This study was undertaken to characterize TP53 mutations and p53 protein immunoreactivity in cancers and preinvasive lesions of Barrett's esophageal mucosa. METHODS: Seventeen Barrett's adenocarcinomas were examined by polymerase chain reaction amplification, denaturant gradient gel electrophoresis, and sequencing...

Topics

Adenocarcinoma
Aged
Aged, 80 and over
Barrett Esophagus
Base Sequence
Esophageal Neoplasms
Female
Genes, p53
Humans
Immunohistochemistry
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mucous Membrane

Mutation

Precancerous Conditions

Staining and Labeling

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 7523212
DOI: 10.1016/0016-5085(94)90225-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7523212-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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