Article
Clinical implications of p53 gene mutation in the progression of Barrett's epithelium to invasive esophageal cancer.
American journal of surgery - 1 Jan 1994
Casson A G, Manolopoulos B, Troster M, Kerkvliet N, O'Malley F, Inculet R, Finley R, Roth J A
Abstract excerpt
The p53 tumor suppressor gene has been implicated in human esophageal tumorigenesis, and mutations are reported in primary esophageal adenocarcinomas and associated Barrett's epithelium. To evaluate the potential clinical significance of this molecular genetic marker in the progression of Barrett...
Topics
- Adenocarcinoma
- Aged
- Barrett Esophagus
- DNA, Single-Stranded
- Esophageal Neoplasms
- Esophagus
- Female
- Genes, p53
- Humans
- Immunoenzyme Techniques
- Male
- Mutation
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53