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Article

Clinical implications of p53 gene mutation in the progression of Barrett's epithelium to invasive esophageal cancer.

American journal of surgery - 1 Jan 1994

Casson A G, Manolopoulos B, Troster M, Kerkvliet N, O'Malley F, Inculet R, Finley R, Roth J A

Abstract excerpt

The p53 tumor suppressor gene has been implicated in human esophageal tumorigenesis, and mutations are reported in primary esophageal adenocarcinomas and associated Barrett's epithelium. To evaluate the potential clinical significance of this molecular genetic marker in the progression of Barrett's epithelium to invasive esophageal cancer, we studied 20 patients with Barrett's epithelium, 10 of whom had an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8311140
DOI: 10.1016/0002-9610(94)90053-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical implications of p53 gene mutation in the progression of Barrett's epithelium to invasive esophageal cancer.PMID 8311140Read ↗

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Mutations of p53 in Barrett's esophagus and Barrett's cancer: a prospective study of ninety-eight cases.Semantic proximity Read ↗

TP53 gene mutations and p53 protein immunoreactivity in malignant and premalignant Barrett's esophagus.Semantic proximity Read ↗

p53 in esophageal adenocarcinoma: a critical reassessment of mutation frequency and identification of 72Arg as the dominant allele.Semantic proximity Read ↗

Abnormal<i>TP53</i>predicts risk of progression in patients with Barrett’s esophagus regardless of a diagnosis of dysplasiaSemantic proximity Read ↗

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TP53 gene mutations are rare in nondysplastic Barrett's esophagus.Semantic proximity Read ↗

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