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A restricted subset of <i>var</i> genes mediates adherence of <i>Plasmodium falciparum</i> -infected erythrocytes to brain endothelial cells

22 May 2012

Abstract excerpt

Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly understood. In this study, P. falciparum-IEs were characterized for binding to primary human brain microvascular endothelial cells (HBMECs). Before selection, CD36 or ICAM-1-binding parasites exhibited punctate binding to a subpopulation...

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PMID: 22619321
DOI: 10.1073/pnas.1120534109

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