Antigenic Variation in <i>Plasmodium falciparum</i> : Gene Organization and Regulation of the <i>var</i> Multigene Family

Abstract excerpt

Plasmodium falciparum imposes an enormous burden upon the developing world, with 300 to 500 million cases and 1 to 2 million deaths per year (94).Despite extensive research efforts, development of parasite drug resistance is a growing problem, and an effective vaccine is still lacking.Individuals living in areas of high P. falciparum transmission acquire protective immunity to severe malaria during early...

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