Article

Transcriptional responses of brain endothelium to <i>Plasmodium falciparum</i> patient-derived isolates <i>in vitro</i>

2024-01-11

Abstract excerpt

A hallmark of cerebral malaria (CM) is sequestration of Plasmodium falciparum infected erythrocytes (IE) within the brain microvasculature. Binding of IE to endothelium reduces microvascular flow and combined with an inflammatory response perturbs endothelial barrier function, resulting in breakdown of the blood- brain barrier (BBB). Cytoadherence leads to activation of the endothelium and alters a range of cell...

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Literature Corpus work: b3105440-2284-5b5d-87da-8a1d93cc3181
DOI: 10.1101/2024.01.11.575088

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