Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a <i>Plasmodium falciparum</i> intercellular adhesion molecule-1 binding domain: A parasite adhesion trait implicated in cerebral malaria

4 Feb 2000

Abstract excerpt

Binding of infected erythrocytes to brain venules is a central pathogenic event in the lethal malaria disease complication, cerebral malaria. The only parasite adhesion trait linked to cerebral sequestration is binding to intercellular adhesion molecule-1 (ICAM-1). In this report, we show that Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) binds ICAM-1. We have cloned and expressed PfEMP1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Drug Transport and Resistance Mechanisms
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10677532
DOI: 10.1073/pnas.040545897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a <i>Plasmodium falciparum</i> intercellular adhesion molecule-1 binding domain: A parasite adhesion trait implicated in cerebral malariaPMID 10677532Read ↗

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral MalariaSemantic proximity Read ↗

High Throughput Functional Assays of the Variant Antigen PfEMP1 Reveal a Single Domain in the 3D7 Plasmodium falciparum Genome that Binds ICAM1 with High Affinity and Is Targeted by Naturally Acquired Neutralizing AntibodiesSemantic proximity Read ↗

Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum -infected erythrocytesSemantic proximity Read ↗

The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis researchSemantic proximity Read ↗

A restricted subset of <i>var</i> genes mediates adherence of <i>Plasmodium falciparum</i> -infected erythrocytes to brain endothelial cellsSemantic proximity Read ↗

DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial CellsSemantic proximity Read ↗

A subset of group A-like <i>var</i> genes encodes the malaria parasite ligands for binding to human brain endothelial cellsSemantic proximity Read ↗

Widespread functional specialization of <i>Plasmodium falciparum</i> erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genomeSemantic proximity Read ↗

Divergent binding sites on intercellular adhesion molecule‐1 (ICAM‐1) for variant Plasmodium falciparum isolatesSemantic proximity Read ↗

Reconstructing ICAM-1-binding var genes of Plasmodium falciparumSemantic proximity Read ↗

Plasmodium falciparum infected erythrocyte induced modulation of host endothelial cellsSemantic proximity Read ↗

PfEMP1-DBL1α amino acid motifs in severe disease states of <i>Plasmodium falciparum</i> malariaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.