Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells

27 Jun 2013

Abstract excerpt

During blood stage infection, Plasmodium falciparum infected erythrocytes (IE) bind to host blood vessels. This virulence determinant enables parasites to evade spleen-dependent killing mechanisms, but paradoxically in some cases may reduce parasite fitness by killing the host. Adhesion of infected erythrocytes is mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1), a family of polymorphic adhesion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Malaria Research and Control
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23825944
DOI: 10.1371/journal.ppat.1003430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial CellsPMID 23825944Read ↗

Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomassSemantic proximity Read ↗

A restricted subset of <i>var</i> genes mediates adherence of <i>Plasmodium falciparum</i> -infected erythrocytes to brain endothelial cellsSemantic proximity Read ↗

A subset of group A-like <i>var</i> genes encodes the malaria parasite ligands for binding to human brain endothelial cellsSemantic proximity Read ↗

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domainsSemantic proximity Read ↗

Expression of specific <i>var</i> gene subtypes is differentially associated with severe malaria syndromesSemantic proximity Read ↗

Common virulence gene expression in adult first-time infected malaria patients and severe casesSemantic proximity Read ↗

Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding.Semantic proximity Read ↗

Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severe casesSemantic proximity Read ↗

The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1Semantic proximity Read ↗

<i>Plasmodium falciparum</i> erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in childrenSemantic proximity Read ↗

Cytoadherence phenotype of Plasmodium falciparum-infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral malaria.Semantic proximity Read ↗

Meta-analysis of Plasmodium falciparum var Signatures Contributing to Severe Malaria in African Children and Indian Adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.