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Article

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

27 Jun 2016

Abstract excerpt

Most severe Plasmodium falciparum infections are experienced by young children. Severe symptoms are precipitated by vascular sequestration of parasites expressing a particular subset of the polymorphic P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion molecules. Parasites binding human endothelial protein C receptor (EPCR) through the CIDRα1 domain of certain PfEMP1 were recently associated with...

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PMID: 27354391
DOI: 10.15252/emmm.201606188

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