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Article

Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass

16 May 2016

Abstract excerpt

The interplay between cellular and molecular determinants that lead to severe malaria in adults is unexplored. Here, we analyzed parasite virulence factors in an infected adult population in India and investigated whether severe malaria isolates impair endothelial protein C receptor (EPCR), a protein involved in coagulation and endothelial barrier permeability. Severe malaria isolates overexpressed specific...

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PMID: 27185931
DOI: 10.1073/pnas.1524294113

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