Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A subset of group A-like <i>var</i> genes encodes the malaria parasite ligands for binding to human brain endothelial cells

22 May 2012

Abstract excerpt

Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite adhesins on the surface of IEs binding to human receptors on microvascular endothelial cells. The parasite and host molecules involved in this interaction are unknown....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Mosquito-borne diseases and control
Share to Parasites and Host Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22619330
DOI: 10.1073/pnas.1120461109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A subset of group A-like <i>var</i> genes encodes the malaria parasite ligands for binding to human brain endothelial cellsPMID 22619330Read ↗

DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial CellsSemantic proximity Read ↗

A restricted subset of <i>var</i> genes mediates adherence of <i>Plasmodium falciparum</i> -infected erythrocytes to brain endothelial cellsSemantic proximity Read ↗

Reconstructing ICAM-1-binding var genes of Plasmodium falciparumSemantic proximity Read ↗

Widespread functional specialization of <i>Plasmodium falciparum</i> erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genomeSemantic proximity Read ↗

High Throughput Functional Assays of the Variant Antigen PfEMP1 Reveal a Single Domain in the 3D7 Plasmodium falciparum Genome that Binds ICAM1 with High Affinity and Is Targeted by Naturally Acquired Neutralizing AntibodiesSemantic proximity Read ↗

<i>Plasmodium falciparum</i> Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A <i>var</i> GenesSemantic proximity Read ↗

Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clonesSemantic proximity Read ↗

Antigenic Variation in <i>Plasmodium falciparum</i> : Gene Organization and Regulation of the <i>var</i> Multigene FamilySemantic proximity Read ↗

Common virulence gene expression in adult first-time infected malaria patients and severe casesSemantic proximity Read ↗

Gene expression profiling of malaria parasites reveals common virulence gene expression in adult first-time infected patients and severe casesSemantic proximity Read ↗

Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151Semantic proximity Read ↗

Expression of specific <i>var</i> gene subtypes is differentially associated with severe malaria syndromesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.