Article
Cytoadherence phenotype of Plasmodium falciparum-infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral malaria.
Malaria journal - 25 Aug 2014
Almelli Talleh, Ndam Nicaise T, Ezimegnon Sem, Alao Maroufou J, Ahouansou Charles, Sagbo Gratien, Amoussou Annick, Deloron Philippe, Tahar Rachida
Abstract excerpt
BACKGROUND: Cytoadherence of Plasmodium falciparum-infected erythrocytes (IEs) in deep microvasculature endothelia plays a major role in the pathogenesis of cerebral malaria (CM). This biological process is thought to be mediated by P. falciparum erythrocyte membrane protein-1 (PfEMP-1) and human receptors such as CD36 and ICAM-1. The relationship between the expression of PfEMP-1 variants and cytoadherence...
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