Article

Expression of specific <i>var</i> gene subtypes is differentially associated with severe malaria syndromes

2026-02-04

Abstract excerpt

The virulence of Plasmodium falciparum is closely linked to P. falciparum erythrocyte membrane protein 1 ( Pf EMP1), encoded by a diverse var gene family. Pf EMP1 mediates parasite immune evasion and vascular adhesion of infected red blood cells, contributing to severe disease. While expression of group A or domain cassettes (DC8 and DC13)-containing var genes have been associated with severe malaria, comparis...

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Literature Corpus work: f151001c-69b7-584f-9a58-3622d5e0924c
DOI: 10.64898/2026.02.02.26345432

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